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Descripción
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This database includes information on the optimal parameters for mass spectrometry detection in MRM mode for the analysis of atropine and scopolamine using the UHPLC-TQ-MS/MS method developed in this work. It also details the textural properties and functionalization degree of the prepared functionalized mesoporous silicas. The Extracted Ion Chromatograms (EIC) of the most intense product ions and Mass Spectra (MS2) obtained for atropine and scopolamine are presented. Additionally, results from X-ray diffraction, transmission electron microscopy, scanning electron microscopy, nitrogen adsorption–desorption, Fourier-transform infrared spectroscopy, 29Si solid-state nuclear magnetic resonance spectroscopy, and elemental analysis are included. The different types of interactions that may occur between tropane alkaloids (TAs) and the MCM-41-SO3H sorbent used for solid-phase extraction are described. Finally, these materials were evaluated as sorbents for strong cation-exchange solid-phase extraction (SPE), determining their efficiency in the adsorption and desorption of tropane alkaloids (atropine and scopolamine). (2025-01-10)
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Notas
| In this work, mesoporous silicas with two types of mesoporous structures were synthesized and functionalized with sulfonic acid groups: MCM-41-SO3H (honeycomblike hexagonal structure) and MSU-2-SO3H (three-dimensional porous structure with wormhole pores). The synthesized materials were characterized by X-ray diffraction, transmission electron microscopy, scanning electron microscopy, nitrogen adsorption–desorption, Fourier-transform infrared spectroscopy, 29Si solid-state nuclear magnetic resonance spectroscopy, and elemental analysis. The obtained functionalized materials were evaluated as sorbents for strong cation-exchange solid-phase extraction (SPE) to determine their efficiency in the adsorption and desorption of tropane alkaloids (atropine and scopolamine). The loading solvents, loading volume, analyte concentration, and elution volume were studied, using 50 mg of both materials. Analyses were carried out by ultra-high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry. The synthesized MCM-41-SO3H material presented the highest recovery efficiency and has proven to be a promising sorbent for strong cation-exchange SPE of atropine and scopolamine in aqueous media. The high degree of functionalization of MCM-41-SO3H and the high accessibility of the sulfonic groups for the target analytes, due to the regularity and uniformity of their pores, maximize the contact between the alkaloids and the sorbent, favoring efficient adsorption. |
